Endocrine Abstracts

Introduction: In vitro monolayer cell cultures are not able to faithfully model the biological features of the three dimensional (3D) structure of solid tumours. There are limited information about the applicability of 3D cell culturing methods for modeling of tumours of endocrine organs.Aim: The aim of our work was the establishment and characterization of three-dimensional in vitro models of various endocrine tumour cells in order to ...

Pheochromocytoma/paragangliomas (Pheo/PGL) are rare neuroendocrine cancers with strong genetic background. Mutations in the SDHB subunit of succinate dehydrogenase (SDH) predispose to malignant disease with limited therapeutic options and poor prognosis. Novel prognostic markers and therapeutic targets are required to decrease the high mortality rate. Glutaminases play a crucial role in the metabolism of SDH impaired tumor cells. By using a host of cellular and molecu...